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Alegre, Maria-Luisa

One or more keywords matched the following properties of Alegre, Maria-Luisa

Property	Value
overview	My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

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overview

My laboratory is interested in T cell responses in settings of transplantation, autoimmunity and cancer, with an emphasis on mouse models and emerging extensions onto clinical translation. A main focus of the laboratory is on T cell tolerance in transplantation and how infections and inflammatory events can affect induction or maintenance of tolerance. We have found that transplantation tolerance can exist at different levels of robustness based on the number of mechanisms of T cell tolerance that are engaged, and that infections or inflammation can erode such tolerance. The impact of bacterial infections on transplant outcomes has led us to discover that the microbiota also influences immune responses to transplanted organs and can be manipulated to prolong graft survival. Our clinical studies have focused on the immunology of transplant recipients and of patients infected with the bacteria that influence transplant outcomes and, collaboratively, we have explored the involvement of the microbiota in the responsiveness of melanoma patients to immunotherapy.

One or more keywords matched the following items that are connected to Alegre, Maria-Luisa

Item Type	Name
Concept	Antigen-Presenting Cells
Concept	Antigens, Ly
Concept	Bone Marrow Cells
Concept	Antigens
Concept	Antigens, Differentiation
Concept	Antigens, Surface
Concept	Antigens, Differentiation, T-Lymphocyte
Concept	Antigens, Bacterial
Concept	Histocompatibility Antigens Class II
Concept	Cell Differentiation
Concept	Cell Movement
Concept	Cell Nucleus
Concept	Cell Membrane
Concept	Cell Division
Concept	Clone Cells
Concept	Cell Cycle
Concept	Dendritic Cells
Concept	Cell Compartmentation
Concept	Epithelial Cells
Concept	Killer Cells, Natural
Concept	Mast Cells
Concept	Plasma Cells
Concept	HLA Antigens
Concept	Receptors, Fc
Concept	H-2 Antigens
Concept	Receptor Aggregation
Concept	Receptors, Antigen, B-Cell
Concept	Receptors, Immunologic
Concept	Receptors, IgG
Concept	Ki-1 Antigen
Concept	CD28 Antigens
Concept	Histocompatibility Antigens Class I
Concept	Langerhans Cells
Concept	Hematopoietic Stem Cell Transplantation
Concept	Th1 Cells
Concept	Tumor Cells, Cultured
Concept	CD8 Antigens
Concept	Receptors, Interleukin-2
Concept	Antigens, CD
Concept	Stem Cell Transplantation
Concept	Antigen Presentation
Concept	B7-1 Antigen
Concept	Receptors, Tumor Necrosis Factor
Concept	Cell Proliferation
Concept	CD40 Antigens
Concept	Th2 Cells
Concept	Antigens, CD19
Concept	Antigens, CD1
Concept	Jurkat Cells
Concept	Receptors, Purinergic P2X7
Concept	B7-H1 Antigen
Concept	COS Cells
Concept	Active Transport, Cell Nucleus
Concept	Receptors, Interleukin-7
Concept	Interleukin Receptor Common gamma Subunit
Concept	HEK293 Cells
Concept	TNF Receptor-Associated Factor 2
Concept	CTLA-4 Antigen
Concept	Interleukin-2 Receptor alpha Subunit
Concept	NK Cell Lectin-Like Receptor Subfamily K
Concept	Toll-Like Receptor 4
Concept	Cell Death
Concept	Minor Histocompatibility Antigens
Concept	CD3 Complex
Concept	Protein Tyrosine Phosphatase, Non-Receptor Type 6
Concept	Receptors, Natural Killer Cell
Concept	Cell Lineage
Concept	B7-2 Antigen
Concept	Antigens, CD1d
Concept	Programmed Cell Death 1 Receptor
Concept	Cell Line, Tumor
Concept	Toll-Like Receptors
Concept	Toll-Like Receptor 9
Concept	Receptor, Notch1
Concept	Lymphoid Progenitor Cells
Concept	Th17 Cells
Concept	Antigen-Antibody Reactions
Concept	Cell Line
Concept	Cell Survival
Concept	Cells, Cultured
Concept	Receptors, Antigen, T-Cell
Concept	Leukemia, T-Cell
Concept	CD4 Antigens
Concept	fas Receptor
Concept	Lymphotoxin beta Receptor
Concept	Interleukin-7 Receptor alpha Subunit
Concept	Protein Tyrosine Phosphatase, Non-Receptor Type 11
Academic Article	Bioactivity of recombinant feline interleukin-2 on human and feline leukocytes.
Academic Article	Interaction of CTLA-4 with the clathrin-associated protein AP50 results in ligand-independent endocytosis that limits cell surface expression.
Academic Article	Humanized OKT3 antibodies: successful transfer of immune modulating properties and idiotype expression.
Academic Article	Tissue distribution, regulation and intracellular localization of murine CD1 molecules.
Academic Article	Regulation of surface and intracellular expression of CTLA4 on mouse T cells.
Academic Article	Impaired negative selection in CD28-deficient mice.
Academic Article	Effect of a single amino acid mutation on the activating and immunosuppressive properties of a "humanized" OKT3 monoclonal antibody.
Academic Article	Role of STAT4 and STAT6 signaling in allograft rejection and CTLA4-Ig-mediated tolerance.
Academic Article	Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28.
Academic Article	Regulation of cytotoxic T lymphocyte-associated molecule-4 by Src kinases.
Academic Article	Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article	Transplantation and the CD28/CTLA4/B7 pathway.
Academic Article	Role of STAT6 signaling in the induction and long-term maintenance of tolerance mediated by CTLA4-Ig.
Academic Article	Different mechanisms of cardiac allograft rejection in wildtype and CD28-deficient mice.
Academic Article	Impaired NF-kappaB activation in T cells permits tolerance to primary heart allografts and to secondary donor skin grafts.
Academic Article	TCR-independent CD30 signaling selectively induces IL-13 production via a TNF receptor-associated factor/p38 mitogen-activated protein kinase-dependent mechanism.
Academic Article	GATA-3: an unexpected regulator of cell lineage determination in skin.
Academic Article	Absence of CTLA-4 lowers the activation threshold of primed CD8+ TCR-transgenic T cells: lack of correlation with Src homology domain 2-containing protein tyrosine phosphatase.
Academic Article	Modulation of tryptophan catabolism by regulatory T cells.
Academic Article	CD8 T cell-mediated rejection of intestinal allografts is resistant to inhibition of the CD40/CD154 costimulatory pathway.
Academic Article	Cutting edge: targeted ligation of CTLA-4 in vivo by membrane-bound anti-CTLA-4 antibody prevents rejection of allogeneic cells.
Academic Article	CTLA-4 engagement regulates NF-kappaB activation in vivo.
Academic Article	Actin cytoskeleton regulates calcium dynamics and NFAT nuclear duration.
Academic Article	Transgenic expression of CTLA-4 controls lymphoproliferation in IL-2-deficient mice.
Academic Article	Transplantation tolerance in NF-kappaB-impaired mice is not due to regulation but is prevented by transgenic expression of Bcl-xL.
Academic Article	Cutting edge: Cbl-b: one of the key molecules tuning CD28- and CTLA-4-mediated T cell costimulation.
Academic Article	Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia.
Academic Article	Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues.
Academic Article	Role of natural killer cell subsets in cardiac allograft rejection.
Academic Article	Costimulatory molecules as targets for the induction of transplantation tolerance.
Academic Article	Cellular mechanisms underlying acute graft rejection: time for reassessment.
Academic Article	Overexpression of program death-1 in T cells has mild impact on allograft survival.
Academic Article	Local expression of B7-H1 promotes organ-specific autoimmunity and transplant rejection.
Academic Article	Toll-like receptor signaling in transplantation.
Academic Article	Fas mediates cardiac allograft acceptance in mice with impaired T-cell-intrinsic NF-kappaB signaling.
Academic Article	The balance of immune responses: costimulation verse coinhibition.
Academic Article	Peripheral survival of naïve CD8+ T cells.
Academic Article	Polymorphisms in CD1d affect antigen presentation and the activation of CD1d-restricted T cells.
Academic Article	The multiple facets of toll-like receptors in transplantation biology.
Academic Article	Toll-like receptors (TLRs) in transplantation.
Academic Article	TLR signals promote IL-6/IL-17-dependent transplant rejection.
Academic Article	Decreased percentage of CD4+FoxP3+ cells in bronchoalveolar lavage from lung transplant recipients correlates with development of bronchiolitis obliterans syndrome.
Academic Article	T-cell receptor-induced NF-kappaB activation is negatively regulated by E3 ubiquitin ligase Cbl-b.
Academic Article	IL-6 induced by Staphylococcus aureus infection prevents the induction of skin allograft acceptance in mice.
Academic Article	The inside story of dendritic cell immunotherapy.
Academic Article	Significant CD4, CD8, and CD19 lymphopenia in peripheral blood of sarcoidosis patients correlates with severe disease manifestations.
Academic Article	Role of T cell-nuclear factor ?B in transplantation.
Academic Article	Mechanisms of CTLA-4-Ig in tolerance induction.
Academic Article	High TCR stimuli prevent induced regulatory T cell differentiation in a NF-?B-dependent manner.
Academic Article	TLR engagement prevents transplantation tolerance.
Academic Article	Attenuation by targeting the B- and T-cell attenuator.
Academic Article	An anti-murine CD3 monoclonal antibody with a low affinity for Fc gamma receptors suppresses transplantation responses while minimizing acute toxicity and immunogenicity.
Academic Article	Immunomodulation of transplant rejection using monoclonal antibodies and soluble receptors.
Academic Article	Epidermal Langerhans cells promote skin allograft rejection in mice with NF-kappa B-impaired T cells.
Academic Article	Prevention of allograft tolerance by bacterial infection with Listeria monocytogenes.
Academic Article	Prevention of the humoral response induced by an anti-CD3 monoclonal antibody by deoxyspergualin in a murine model.
Academic Article	Severe combined immunodeficient mice engrafted with human splenocytes have functional human T cells and reject human allografts.
Academic Article	Endocytic sequestration of the B cell antigen receptor and toll-like receptor 9 in anergic cells.
Academic Article	CARMA1 controls an early checkpoint in the thymic development of FoxP3+ regulatory T cells.
Academic Article	Role of T-cell-specific nuclear factor ?B in islet allograft rejection.
Academic Article	T cell receptor/CARMA1/NF-?B signaling controls T-helper (Th) 17 differentiation.
Academic Article	Expression and function of CTLA-4 in Th1 and Th2 cells.
Academic Article	CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves' disease.
Academic Article	CD28/B7 regulation of anti-CD3-mediated immunosuppression in vivo.
Academic Article	Formation of a central supramolecular activation cluster is not required for activation of naive CD8+ T cells.
Academic Article	Antagonistic effect of toll-like receptor signaling and bacterial infections on transplantation tolerance.
Academic Article	IFN-?: The Dr. Jekyll and Mr. Hyde of immunology?
Academic Article	Basal NF-?B controls IL-7 responsiveness of quiescent naïve T cells.
Academic Article	I spy alloreactive T cells.
Academic Article	STING-dependent cytosolic DNA sensing mediates innate immune recognition of immunogenic tumors.
Academic Article	T cell-NF-?B activation is required for tumor control in vivo.
Academic Article	Analysis of GzmbCre as a Model System for Gene Deletion in the Natural Killer Cell Lineage.
Academic Article	T-cell regulation by CD28 and CTLA-4.
Academic Article	Proteomic Identification of saeRS-Dependent Targets Critical for Protective Humoral Immunity against Staphylococcus aureus Skin Infection.
Academic Article	Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy.
Academic Article	Cutting Edge: Engineering Active IKKß in T Cells Drives Tumor Rejection.
Academic Article	Tumor-associated fibroblasts predominantly come from local and not circulating precursors.
Academic Article	The composition of the microbiota modulates allograft rejection.
Academic Article	Delayed Cytotoxic T Lymphocyte-Associated Protein 4-Immunoglobulin Treatment Reverses Ongoing Alloantibody Responses and Rescues Allografts From Acute Rejection.
Academic Article	Antigen Presentation in Transplantation.
Academic Article	Adoptive Transfer of Tracer-Alloreactive CD4+ T Cell Receptor Transgenic T Cells Alters the Endogenous Immune Response to an Allograft.
Academic Article	Natural killer cell subsets in allograft rejection and tolerance.
Academic Article	Super-MANF to the Rescue: Immunomodulation Improves Retinal Repair and Regenerative Cell Therapy.
Academic Article	Tracking of TCR-Transgenic T Cells Reveals That Multiple Mechanisms Maintain Cardiac Transplant Tolerance in Mice.
Academic Article	The Multiple Molecular Paths of Antibody Suppression by TFR Cells.
Academic Article	Dendritic Cell Identification for Dummies.
Academic Article	Ionic Checkpoint: Potassium-Driven T Cell Immunosuppression.
Academic Article	The Tpm Subset of the CD8+ T Cell Memory Family.
Academic Article	Evolving Approaches in the Identification of Allograft-Reactive T and B Cells in Mice and Humans.
Academic Article	Successful Treatment of T Cell-Mediated Acute Rejection with Delayed CTLA4-Ig in Mice.
Academic Article	Danger, Metabolism and T Cell Memory.
Academic Article	Sweet T Cell Dysfunction.
Academic Article	The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients.
Academic Article	Novel Role of Calcineurin Inhibitors in Curbing T Cells' Sweet Tooth.
Academic Article	Equal Expansion of Endogenous Transplant-Specific Regulatory T Cell and Recruitment Into the Allograft During Rejection and Tolerance.
Academic Article	DC Metabolism Controls Lung T Cell Polarization.
Academic Article	Th17 Cells Changing Colors.
Academic Article	T Cell Receptor-Regulated TGF-ß Type I Receptor Expression Determines T Cell Quiescence and Activation.
Academic Article	Metabolic Control of T Cell Memory.
Academic Article	Distinct Graft-Specific TCR Avidity Profiles during Acute Rejection and Tolerance.
Academic Article	The Adaptive NK Cell Response.
Academic Article	Gut Microbiota Can Impact Chronic Murine Lung Allograft Rejection.
Academic Article	Thymic regulatory T cells arise via two distinct developmental programs.
Academic Article	B cells, CMV, and stem cell transplant.
Academic Article	The pursuit of transplantation tolerance: new mechanistic insights.
Academic Article	Neuroimmunology and the control of T cell migration.
Grant	Impact of Microbiota on Alloimmune Responses in Transplantation
Grant	Infections and the Stability of Transplantation Tolerance
Grant	The microbiota and allograft rejection: novel investigations into the consequences of obesity
Academic Article	Skin-restricted commensal colonization accelerates skin graft rejection.
Academic Article	Innate lymphoid cells coming of age.
Academic Article	Resilience of T cell-intrinsic dysfunction in transplantation tolerance.
Academic Article	DeTOXifying exhausted T cells.
Academic Article	Pathogenic Bhlhe40+ GM-CSF+ CD4+ T cells promote indirect alloantigen presentation in the GI tract during GVHD.
Academic Article	In vivo and in vitro differences in CD8+ T cell metabolism.
Academic Article	Giving effector/memory T cells a new (suppressive) purpose.
Academic Article	Exploiting immunometabolism and T cell function for solid organ transplantation.
Academic Article	Inhibition of protective immunity against Staphylococcus aureus infection by MHC-restricted immunodominance is overcome by vaccination.
Academic Article	Transplantation tolerance modifies donor-specific B cell fate to suppress de novo alloreactive B cells.
Academic Article	The anti-inflammatory function of the apoptotic secretome.
Academic Article	Introduction to this Cellular Immunology issue on new advances in solid organ transplantation immunology.
Academic Article	Pregnancy-induced humoral sensitization overrides T cell tolerance to fetus-matched allografts in mice.
Academic Article	Regulation of Alloantibody Responses.
Academic Article	Toward an understanding of allogeneic conflict in pregnancy and transplantation.
Academic Article	Oral alloantigen exposure promotes donor-specific tolerance in a mouse model of minor-mismatched skin transplantation.
Academic Article	Linked sensitization by memory CD4+ T cells prevents costimulation blockade-induced transplantation tolerance.
Academic Article	Reduced Satb1 expression predisposes CD4+ T conventional cells to Treg suppression and promotes transplant survival.
Concept	B-Cell CLL-Lymphoma 10 Protein
Grant	Role of NF-kB Activation in Acute Allograft Rejection
Grant	Mechanisms of TLR-mediated prevention of transplantation tolerance
Grant	Role of NF-kB Activation in Acute Allograft Rejection
Grant	NF-kappaBeta activation T cell function/graft rejection
Academic Article	Pregnancy programs epigenetic and transcriptional exhaustion in memory CD8+ T cells.
Academic Article	Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.
Academic Article	Methods to Study TLRs in Transplantation.
Academic Article	Biological Time Travel: Tracking the Journey of Alloreactive T Cells Through Longitudinal Biobanking.
Academic Article	Heterogeneity in allospecific T cell function in transplant-tolerant hosts determines susceptibility to rejection following infection.
Academic Article	Sex, T Cells, and the Microbiome in Natural ABO Antibody Production in Mice.
Academic Article	Low-affinity CD8+ T cells provide interclonal help to high-affinity CD8+ T cells to augment alloimmunity.

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